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Propofol has emerged in the last decade as the most widely used IV anaesthetic drug in the world. It has a favourable safety profile and low reported rates of adverse drug reactions. Reports describing propofol-related adverse reactions leading to hospital admission are very rare. A prospective case-control study was conducted in order to search for associated risk factors for hospital admission due to adverse reactions related to the use of propofol. Consecutive patients who received propofol in the Intensive Care Unit (ICU) of a University Hospital during January-July 1998 were included in the study. Cases of hospital admission due to adverse reactions to propofol were identified from the ICU admission and discharge medical records. A control was randomly selected for each case from the ICU admission and discharge medical records of patients who did not develop any adverse reaction to propofol during the hospital stay. Fourteen cases of adverse reactions were identified from a total of 1142 propofol administrations. Among these, 11 (79.3%) were due to the induction dose, and 3 (21.4%) to the maintenance dose. The risk of hospital admission due to adverse reactions to propofol increased with the number of doses administered (OR 2.32; 95% CI: 1.14-4.71; P = 0.02) and it was significantly higher in patients older than 50 years of age (OR 2.92; 95% CI: 1.04-8.21; P = 0.04) and in patients with chronic renal failure (OR 5.54; 95% CI: 1.51-20.58; P = 0.01). The use of propofol, particularly the induction dose, carries a significant risk of hospital admission due to
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