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www.taildownload.tk · All_books · Sell Book · raag parichay book pdf 601Use of adjuvants in oral poliovirus vaccines: studies in mice, monkeys, and humans.
Adjuvants are currently being used in some oral poliovirus vaccines in order to augment the immunogenicity of the oral polio vaccine (OPV). Adjuvants may enhance the immune responses to the vaccine antigen. Adjuvants also may have undesirable effects on the host. The purpose of this review is to summarize knowledge of adjuvants used in oral poliovirus vaccines and to discuss the issues related to the use of adjuvants in OPV. The following search strategy was used to find published literature in English, French, Spanish, Portuguese, and Japanese: Adjuvant, Epitope vaccine, Food, Disease, Vaccine, or Vaccine adjuvant. The search was restricted to the period from 1990 to March 2001. All vaccine preparations against poliomyelitis that used adjuvants were included. Human and animal data using adjuvants in oral poliovirus vaccine preparations were reviewed. Adjuvants are indispensable for the development of the vaccine against poliomyelitis. However, the effects of adjuvants on the host are a matter of concern. Adjuvants may interact with the gut microflora, the gastrointestinal and central nervous system, cellular immune response, and blood cells. The effects of adjuvants on the development of poliovirus-specific immune responses vary, and even contradictory effects have been reported in some studies. Little information is available about the effects of adjuvants in other vaccines. Further studies on adjuvants are needed for the development of safer vaccines.Sensitivity of gastric tone to nitric oxide in an animal model of gastritis.
To study the role of nitric oxide (NO) in the regulation of gastric tone in gastritis, we used an animal model of gastritis in which gastric submucosa is progressively replaced by fibrous tissue resulting in progressive reduction of the capacity of the antrum to resist to distention. The antrum of guinea pigs was progressively replaced by fibrous tissue. The nNOS expression was evaluated in the stomach over time by immunohistochemistry and Western blot. The extent and the intensity of nNOS in the antrum and fundus were evaluated by Western blot. The effects of exogenous nit
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